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1. A 49-year-old woman presented with a slowly enlarging lump in her neck.
On examination, there was a 3.5-cm firm nodule in the left lobe of the thyroid gland, with no associated lymphadenopathy.
Investigations:
serum thyroid-stimulating hormone<0.05 mU/L (0.4-5.0)
serum free T426.0 pmol/L (10.0-22.0)
serum free T38.6 pmol/L (3.0-7.0)
An ultrasound scan showed an enlarged thyroid gland, with small nodules throughout. There was a larger hypoechoic 3.3-cm nodule with increased intranodular vascularity in the lower pole of the left lobe, with no associated lymphadenopathy.
What is the most appropriate management?
A) isotope uptake scan
B) core biopsy of the thyroid nodule
C) partial thyroidectomy
D) radioactive iodine treatment
E) fine-needle aspiration of the nodule
2. A 57-year-old man was admitted to hospital with joint pains. He was found to have gout. He had been found to have type 2 diabetes mellitus at the age of 47 years and developed nephropathy 7 years later. He was taking metformin 1 g twice daily, ramipril 5 mg twice daily and gliclazide 80 mg twice daily. The admitting team advised him to take ibuprofen 400 mg three times daily as needed.
On examination, his pulse was 87 beats per minute and his blood pressure was 146/85 mmHg. He had an inflamed right hallux.
Investigations:
serum sodium131 mmol/L (137-144)
serum potassium5.1 mmol/L (3.5-4.9)
serum creatinine156 umol/L (60-110)
estimated glomerular filtration rate (MDRD)42 mL/min/1.73 m2 (>60)
haemoglobin A1c72 mmol/mol (20-42)
random plasma glucose23.0 mmol/L
What is the most appropriate step in management?
A) stop gliclazide and ibuprofen
B) stop gliclazide and withhold metformin
C) withhold metformin alone
D) stop ibuprofen alone
E) stop ibuprofen and withhold metformin
3. A 62-year-old woman was referred with difficulty in swallowing and a painful, swollen neck.
On examination, her neck was tender to palpation with a small, diffuse goitre. There was no
associated neck lymphadenopathy.
Investigations:
serum thyroid-stimulating hormone<0.04 mU/L (0.4-5.0)
serum free T426.0 pmol/L (10.0-22.0)
serum free T312.0 pmol/L (3.0-7.0)
What is the most likely diagnosis?
A) thyroid carcinoma
B) Graves' disease
C) haemorrhage into a thyroid cyst
D) toxic adenoma
E) subacute thyroiditis
4. A 25-year-old woman who was 4 months pregnant presented with weight loss of 3 kg over the previous 4 weeks, associated with intermittent palpitations, tremor and feeling of warmth. She was not taking any medication.
On examination, her pulse was 100 beats per minute and regular, and her blood pressure was 130/60 mmHg. A symmetrical non-tender goitre was palpable, with an audible bruit. There was no exophthalmos.
Investigations:
serum thyroid-stimulating hormone<0.1 mU/L (0.4-5.0)
serum free T445.2 pmol/L (10.0-22.0)
serum free T322.8 pmol/L (3.0-7.0)
anti-thyroid stimulating hormone receptor
antibodies40 U/L (<7)
What is the most appropriate treatment?
A) subtotal thyroidectomy
B) radioactive iodine
C) propranolol
D) carbimazole
E) propylthiouracil
5. A 45-year-old woman attended for annual follow-up for long-standing hypoparathyroidism (a complication of thyroid surgery 5 years previously). She was asymptomatic. She was taking alfacalcidol 1 microgram daily.
Examination was unremarkable.
Investigations:
serum creatinine105 umol/L (60-110)
serum corrected calcium2.45 mmol/L (2.20-2.60)
24-h urinary calcium9.8 mmol (2.5-7.5)
What is the most appropriate next step in management?
A) change alfacalcidol to calcitriol
B) add bendroflumethiazide
C) decrease alfacalcidol dosage
D) change alfacalcidol to teriparatide
E) recommend low-calcium diet
Solutions:
| Question # 1 Answer: A | Question # 2 Answer: E | Question # 3 Answer: E | Question # 4 Answer: D | Question # 5 Answer: C |
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